Since the 1970s, our doctors and patients have participated in a wide variety of behavioral and biomedical studies focusing on substance use and its complications, including HIV-related research beginning in the late 1980s. Our research has been funded by the National Institute on Drug Abuse; the National Institute of Allergy and Infectious Diseases; the Centers for Disease Control and Prevention; Bristol-Myers Squibb; GlaxoSmithKline; Abbott Labs; Pfizer Inc.; Ortho Biotech Products, L.P; and OraSure Technologies, Inc. START continues to share the results of its research through scientific presentations across the nation and the world, and in articles found throughout renowned scientific journals.
Fast, N., van Kessel, R., Humphreys, K. et al. The Evolution of Telepsychiatry for Substance Use Disorders During COVID-19: a Narrative Review. Curr Addict Rep 10, 187–197 (2023). DOI 10.1007/s40429-023-00480-9
Ventuneac A, Hecht G, Forcht E, Duah BA, Tarar S, Langenbach B, Gates J, Cain D, Rendina HJ, Aberg JA and Perlman DC (2021) Chronic High Risk Prescription Opioid Use Among Persons With HIV. Front. Sociol. 6:645992. doi: 10.3389/fsoc.2021.645992
Talal AH, Ding Y, Venuto CS, Chakan LM, McLeod A, Dharia A, Morse GD, Brown LS, Markatou M, Kharasch ED. Toward precision prescribing for methadone: Determinants of methadone deposition. PLOS ONE (April 17, 2020): 15(4): 1-24
Louie B, Kritz SA, Brown LS, Chu M, Madray C, Zavala R. Electronic health information system at an opioid treatment programme: roadblocks to implementation. Journal of Evaluation in Clinical Practice 2012:18(4):734-8.
Kritz SA, Brown LS, Chu M, John-Hull C, Madray C, Zavala R, Louie B. Electronic medical record system at an opioid agonist treatment programme: study design, pre-implementation results and post-implementation trends. Journal of Evaluation in Clinical Practice 2012:18(4):739-45.
Wisner KL, Conley RR, Taylor SF, Kosten T, Brown LS. Researcher experiences with IRBs: A survey of members of the American College of Neuropsychopharmacology. IRB: Ethics and Human Research 2011: 14-19.
Alcohol education provided to opioid treatment program patients: results of a nationwide survey. Strauss SM, Harris G, Katigbak C, Rindskopf DM, Singh S, Greenblum I, Brown LS Jr, Kipnis S, Kritz SA, Parrino MW. J Drug Educ. 2010; 40(4):379-93.
Brown LS, Kritz SA, Muhammad A,. Bini EJ, Louie B, Robinson J, Alderson D, Rotrosen J. Substance abuse treatment as HIV prevention: more questions than answers. Journal of National Med Assoc 2010:102: 1183-1191.
Harris GH, Strauss SM, Katigbak C, Brar BS, Brown LS, Kipnis SS, Kritz SA. Variations among state-level approaches to addressing alcohol abuse in opioid treatment programs. Journal of Substance Abuse Treatment 2010: 39: 58-64.
Barthwell AG, Brown LS. The Treatment of Drug Addiction: An Overview in Principles of Addiction Medicine 3rd Edition. Editors: Graham AW, Schultz TK, Mayo-Smith MF, Ries R, Wilford BB; Lippincott,Williams, Wilkins. Philadelphia 2009; pages: 349-359
Kritz S, Chu M, John-Hull C, Madray C, Louie B, Brown LS. Opioid dependence as a chronic disease: The interrelationships between length of stay, methadone dose and age on treatment outcome at an urban opioid treatment program Journal of Addictive Diseases 2009:28: 53-56.
Brown LS. ,,,et. al. Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multi-center trial of Buprenorphine-naloxone and clonidine in the NIDA Clinical Trials Network. Drug and Alcohol Dependence 2009: 99: 28-36.
Tracy K, Brown LS, Kritz SA, Alderson D, Robinson J, Bini, EJ, Levy M, Calsyn D, Rieckmann T, Fuller, B, McAuliffe P, Rotrosen J. Substance abuse treatment clinician opinions and infectious disease service delivery. Journal of Addictive Diseases (in press)
Kritz SA, Brown LS, Goldsmith RJ, Bini EJ, Robinson J, Alderson D, Novo P, Rotrosen J. States and Substance Abuse Treatment Programs: Funding and Guidelines for Infection-Related Services. American Journal of Public Health 2008:98: 824-826.
Amass L , Ling W, Freese TE, Reiber C, Annon JJ, Cohen AJ, McCarty D, Reid MS, Brown LS., Clark C, Ziedonis DM, Krejci J, Stine S, Winhusen T, Brigham G, Babcock D, Muir J A, Buchan BJ, Horton T. Bringing Buprenorphine-Naloxone Detoxification to Community Treatment Providers: The NIDA Clinical Trials Network Field Experience. The American Journal on Addictions, 2004;13:S42-S6
Brown LS, John S, Substance Abuse Prevention in African-American Communities. In:Kar SB(Ed): Substance Abuse Prevention A Multicultural Perspective. Baywood Publishing Company, Inc. Amityville, New York 1999, pages 171-184
Walter L, Charuvastra C, Collins JF, Batki S, Brown LS, Kintaudi P, Wesson DR, McNicholas L, Tusel DJ, Malkerneker U, Renner JA, Santos E, Casadonte P, Fye C, Stine S, Want RIH, Segal D. Buprenorphine Maintenance Treatment of Opiate Dependence: A Multicenter, Randomized Clinical Trial. Addiction 1998; 93(4): 475-486
McDermott PA, Alterman AI, Brown L, Zaballero A, Snider EC, McKay JR. Construct refinement and confirmation for the Addiction Severity Index. Marlatt GA, VandenBos GR (Eds.). Addictive Behaviors, American Psychological Association, Washington, D.C., 1997.
Nurco DN, Primm BJ, Lerner M, Stephenson P, Brown LS, Ajuluchukwu DC. Changes in locus-of-control attitudes about drug misuse in a self-help group in a methadone maintenance clinic. The International J Addictions. 1995;30:765-778.
Alterman, AI, Zaballero A, Lin MM, Siddiqui N, Brown LS, Rutherford MJ. Personality assessment inventory (PAI) scores of lower socioeconomic African-American and Latino methadone maintenance patients. Assessment 1995;2:91-100.
Batson HW, Brown LS, Zaballero A, Faulcon-Gary J. A multicomponent model for substance abuse treatment: the Addiction Research and Treatment Corporation. Journal of Substance Abuse Treatment 1992;9:177-181.
Bini EJ, Kritz SA, Brown LS, Robinson J, Alderson D, Rotrosen J. Barriers to providing health services for HIV/AIDS, hepatitis C virus infection, and sexually transmitted infections in substance abuse treatment programs in the United States. Journal of Addictive Diseases. 2011:30:98-109
Brown LS, Kritz SA, Muhammad A,. Bini EJ, Goldsmith RJ, Robinson J, Alderson D, Hasin DS, Rotrosen J. Disparities in health services for HIV/AIDS, hepatitis C virus, and sexually transmitted infections: role of substance abuse treatment programs. Journal of Addiction Medicine 2009:3: 95-102.
Brown LS, Kritz SA, Goldsmith RJ, Bini EJ, Robinson J, Alderson D, Rotrosen J. Health services for HIV/AIDS, HCV, and sexually transmitted infections in substance abuse treatment programs. Public Health Reports 2007: 122: 441-451
Brown LS, Kritz SA, Goldsmith JR, Rotrosen J, Baker S, Robinson J, McAuliffe P. Characteristics of Substance Abuse Treatment Programs Providing Services for HIV/AIDS, Hepatitis C Virus Infection, and Sexually Transmitted Infections: The National Clinical Trials Network. Journal of Substance Abuse Treatment; 2006:30:315-321
Brown LS, Kritz S, Chu M, Madray C. Safety, Efficacy, and Tolerability of Nelfinavir-Containing Antiretroviral Therapy for Patients Coinfected with HIV and Hepatitis C Undergoing Methadone Maintenance. Journal of Substance Abuse Treatment; 2006:30:331-335.
Rawlings KM, Thompson M, Farthing C, Brown, LS, Racine J, Scott RC, Crawford KH, Goodwin D, Tolson JM, Williams VC, and Shaefer MS. for the NZTA4006. Helping to Enhance Adherence to Antiretroviral Therapy (HEART) Study Team. J.Acquir Immune Defic Syndr 2003;34:174-183
Gordin FM, Matts, JP, Miller C, Brown LS, Hafner R, John SL, Klein M, Vaughin A, Besch LC, Perez G, Szabo S, El-Sadr W. A controlled trial of isoniazid in persons with anergy and human immunodeficiency virus infection who are at high risk for tuberculosis. N Engl J Med. 1997;337:315-20.
Brown LS, Sawyer RC, Li R, Cobb MN, Colborn DC, Narang PK. Lack of a pharmacologic interaction between rifabutin and methadone in HIV-infected former injecting drug users. Drug and Alcohol Dependence, 1996;43:71- 77.
Webster CT, Gordin FM, Matts JP, Korvick JA, Miller C, Muth K, Brown LS, Besch CL, Kumi JO, Salveson C, Bincsik A, Irvin K, Maiatico G. Two-stage tuberculin skin testing in individuals with human immunodeficiency virus infection. Am J Resp Crit Care Med. 1995;151:805-808.
Melnick SL, Sherer R, Louis TA, Hillman D, Rodriguez EM, Lackman C, Capps L, Brown LS, Carlyn M, Vermund SH, Korvick JA, Deyton L. Survival and disease progression according to gender of patients enrolled in the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). JAMA. 1994;272:1915-1921.
Jacobson M, Besch CL, Child C, Hafner R, Matts JP, Muth K, Wentworth DN, Neaton JD, Abrams D, Rimland D, Perez G, Grant IH, Saravolatz LD, Brown LS, Deyton L. Primary prophylaxis with pyrimethamine for toxoplasmic encephalitis in patients with advanced HIV disease: results of a randomized trial. J Infect Dis 1994;169:384-94.
Ajuluchukwu DC, Brown LS, Crummey FC, Foster KF, Ismail YI, Siddiqui N. Demographic, medical history and sexual correlates of HIV Seropositive methadone maintained women. J Addictive Dis 1993;12:105-120.
Siddiqui NS, Brown LS, Meyer TJ, Gonzalez V. Decline in HIV-1 seroprevalence and low seroconversion rate among injecting drug users at a methadone maintenance program in New York City. J Psychoactive Drugs 1993;25:245-250.
Brown LS, Chu A, Allain JP, et al. Seroepidemiology and clinical aspects of human T-cells lymphotropic virus type I/II infection in a cohort of New York City intravenous drug users. New York State J Med 1991;91:93-97.
Boto WMO, Brown LS, Chrest J, Adler WH. Distinct modulatory effects of bryostatin I and staruosporine on the biosynthesis and expression off the HIV receptor protein (CD4) by T-cells. Cell Regulation 1991;2:95-103.
Brown LS. Clinical aspects of drug abuse in diabetes. Diabetes Spectrum 1991;4:45-47.
Brown LS. The impact of AIDS on drug abuse treatment. In: Pickens RW, Leukefeld CG, Schuster CR (Eds): Improving Drug Abuse Treatment, National Institute on Drug Abuse, Research Monograph 106, 1991. DHHS publication no. (ADM) 91-1754, pages 385-393.
Brown LS, Primm BJ. A perspective on the spread of AIDS among minority intravenous drug abusers. In: AIDS and Intravenous Drug Abuse Among Minorities. National Institute on Drug Abuse 1990, DHHS Publication no.(ADM) 90-1637, pages 3023.
Brown LS. Black intravenous drug users: prospects for intervening in the transmission of human immunodeficiency virus infection. In: Leukeld CG, Battjes RJ, Amsel Z (Eds): AIDS and Intravenous Drug Use: Future Directions for Community-based Prevention Research. National Institute on Drug Abuse. Research Monograph 93, 1990. DHHS publication no. (ADM) 90-1627, pages 53-67.
Baker LF, Brown LS, Des Jarlais DC, et al. AIDS and IV drug use. In: CF Turner, HG Miller, LE Moses (Eds): AIDS Sexual Behavior and Intravenous Drug Use. National Research Council. National Academy Press, 1989. Washington DC, pages 186-255.
Brown LS, Murphy DL, Primm BJ. The acquired immunodeficiency syndrome: do drug dependency and ethnicity share a common pathway. In: Harris L (Ed): Problems of Drug Dependence, 1987: Proceedings of the 49th Annual Scientific Meeting. Committee on Problems of Drug Dependence. National Institute on Drug Abuse Research Monograph 81, 1988. DHHS publication no. (ADM) 88-1564, pages 188-194.
Hepatitis C Virus Research
Talal AH , Jaanimagi U, Davis K , Bailey J, Bauer BM a , Dharia A , George S , McLeod A , Morton K , Nugent A , Zeremski M , Dinani A , Des Jarlais DC, Perumalswami PV, Tobin JN , Suzanne S. Dickerson. Facilitating engagement of persons with opioid use disorder in treatment for hepatitis C virus infection via telemedicine: Stories of onsite case managers. April 20, 2021 DOI:https://doi.org/10.1016/j.jsat.2021.108421
Talal AH, Andrews P, Mcleod A, Chen Y, Sylvester C, Markatou M, Brown LS. Integrated, Co-located, Telemedicine-based Treatment Approaches for Hepatitis C Virus (HCV) Management in Opioid Use Disorder Patients on Methadone. Clin Infect Dis 2019; 69: 323-31.
Talal AH, McLeod A, Andrews P, Nieves-McGrath H, Chen Y, Reynolds A, Sylvester C, Dickerson SS, Markatou M, Brown LS. Patient Reaction to Telemedicine for Clinical Management of Hepatitis C Virus Integrated into an Opioid Treatment Program. Telemedicine and E-Health, 2019; 25: 791-801.
Talal A, Chen Y, Zeremski M, Zavala R, Sylvester C, Kuhns M, Brown LS, Markatou M, Cloherty G. Hepatitis C Virus Core Antigen: A Potential Alternative to HCV RNA Testing among Persons with Substance Abuse Disorders. Journal of Substance Abuse Treatment (2017) 78:37-42.
Zeremski M, Zavala R, Dimova RB, Chen Y, Kritz S, Sylvester C, Brown LS, Talal AH. Improvements in HCV-related Knowledge Among Substance Users on Opioid Agonist Therapy After an Educational Intervention. Journal of Addiction Medicine (2016 March/April) 10(2): 104-9.
Brown LS. Talal A, Andrews P, McLeod A, Zeremski, Chen Y, Sylvester C. Integrated telemedicine-based treatment for hepatitis C at an opioid agonist treatment program. Drug and Alcohol Dependence. 2016; 171
Bini EJ, Kritz S, Brown LS Jr, Robinson J, Calsyn D, Alderson D, Tracy K, McAuliffe P, Smith C, Rotrosen J. Hepatitis B virus and hepatitis C virus services offered by substance abuse treatment programs in the United States. J Subst Abuse Treat. 2012 Jun;42(4):438-45. doi: 10.1016/j.jsat.2011.09.007. Epub 2011 Oct 27.
Hepatitis C virus-related knowledge and willingness to receive treatment among patients on methadone maintenance.
Hepatitis C virus control among persons who inject drugs requires overcoming barriers to care.
Advancing equity, diversity, and inclusion in the American College of Neuropsychopharmacology (ACNP): advances, challenges, and opportunities to accelerate progress.
Henningfield, J.E., Fields, S., Anthony, J.C. et al. Advancing equity, diversity, and inclusion in the American College of Neuropsychopharmacology (ACNP): advances, challenges, and opportunities to accelerate progress. Neuropsychopharmacol. (2020). https://doi.org/10.1038/s41386-020-0784-y